Nevertheless, CNS S1PR1 activation has also been reported in conditions with cisplatin-induced cognitive impairment (Squillace et al., 2022), and peripheral administration of either agonist or functional S1PR1 antagonist can ameliorate spatial memory impairment (Asle-Rousta et al., 2013; Zhang et al., 2020). Here, S1PR1 is linked to Cognitive impairment.