INS and metabolic syndrome: Some studies have suggested that dyslipidemia is an insufficient predictor of LUTS and benign prostatic hyperplasia.(21,30) Other chronic metabolic changes, such as increased HbA1c, insulin, and type-2 diabetes mellitus, may be related to this process.(30) Although statistically significant, the association between total cholesterol and LUTS may have been an incidental finding in this population sample, and further studies are necessary to clarify the role of each type of cholesterol in LUTS.