Studies comparing laboratory test results have shown improvements after CCP transfusion.(2) Blood counts have an important prognostic value for managing patients with COVID-19.(8) Moreover, derived indices, such as the neutrophil-to-lymphocyte ratio (NLR), showed good predictive value for disease severity and mortality.(9,10) In addition, the C-reactive protein (CRP)-to-lymphocyte ratio was found to predict the occurrence of pneumonia in patients with COVID-19.(9) These indices may be used as markers of the inflammatory state of patients during transfusion. The gene discussed is CRP; the disease is COVID-19.