PDE2A and diffuse large B-cell lymphoma: As shown in Figure 8B, PDE2A expression had significant negative correlations with TMB in PAAD, STAD, PRAD, STES, BRCA, LIHC, KIRP, HNSC, LGG, THCA (P<0.001), lymphoid neoplasm diffuse large B-cell lymphoma (DLBC), and CESC (P<0.05), while positively correlated in THYM (P<0.001).