However, an intriguing phenomenon was revealed in the survival curve: some tumors exhibited better prognosis when PDE2A expression was high (such as KIRC, LGG, and LIHC), while others showed poorer prognosis (such as BLCA, OV, and STAD), indicating a complex and context-dependent role of PDE2A in cancer progression (Figure 4). Here, PDE2A is linked to cancer.