Moreover, among the top 100 PDE2A-associated genes downloaded from GEPIA2.0, the top four genes were Semaphorin-6B (SEMA6B) (R=0.64), RUN domain containing 3B (RUNDC3B) (R=0.56), calcium uptake protein 3 (MICU3) (R=0.55), and potassium channel subfamily K member 3 (KCNK3) (R=0.53) (all P-values <0.001), which exhibited high correlations with PDE2A across most cancers (Figure 10B). This evidence concerns the gene PDE2A and cancer.