HK2 has been proven to be active by the PI3K-AKT pathway in many reports.41 The plant-derived alkaloids could mediate various types of death, such as apoptosis, ferroptosis, and autophagy, and regulate the cancer progression depending on the tumor microenvironment.42 The tumor microenvironment can be modulated by the PI3K pathway,43 suggesting a potential relationship between the PI3K pathway and HK2. The gene discussed is HK2; the disease is cancer.