Most lactate in the body is produced via glycolysis, a rate-limited process by hexokinase (HK).19 Whether Daurisoline inhibits lung cancer through HK2 remains unclear, as the AKT-GSK3β pathway could regulate HK,20 and there are reports indicating that Daurisoline inhibits the activity of AKT.20 We postulate that Daurisoline can suppress lung cancer growth by regulating the AKT-GSK3β-HK axis that governs lactate production in the tumor microenvironment. The gene discussed is HK2; the disease is lung cancer.