Together, the data show that our non-replicating AdV.C3-Tat/HIV-Box A vectors are inflammation-regulated and sufficiently active in vitro and in vivo to induce rBox A in response to potent non-infectious or infectious inflammatory stimuli (e.g., LPS or influenza) and AdV.C3-Tat/HIV-Box A constructs protect against influenza-induced disease. This evidence concerns the gene TAT and influenza.