The upregulated secretion of IL‐1β/IL‐18 from neutrophils carrying MEFV variants accelerates the secretion of neutrophil chemotactic factors, including IL‐36γ, IL‐8, CCL20, CXCL1, and CXCL2 from keratinocytes via NFκB signaling, leading to neutrophil chemotaxis and to inflammation, which forms pustules in GPP lesions.13 The gene discussed is IL1B; the disease is psoriasis 14, pustular.