Noteworthy examples include the detection of Epidermal Growth Factor Receptor (EGFR) and HER2 in EVs in the context of breast cancer[44], glypican-1 (GPC-1) for pancreatic neoplasms[45], a-IGF-1R in relation to lung carcinoma, claudin-4 with ovarian cancer[46], and Annexin V, EpCAM, and ASGPR1 in the diagnosis of hepatic malignancies[47]. This evidence concerns the gene EGFR and breast carcinoma.