EVs derived from osteotropic LCP melanoma cells appear to stimulate the osteotropic behavior of SK-Mel28 and WM-266, non-osteotropic tumor cells, toward bone in a CXCL12-stimulated manner through the atypical chemokine receptor 3 (ACKR3)/CXCR4 axis [Figure 3B][71]. This evidence concerns the gene CXCL12 and neoplasm.