Several studies have already shown that modulating certain proteins or lipids (e.g., Rab27a, nSMase2, farnesyl transferase, Ras, ceramide) involved in the biogenesis and secretion mechanisms of EVs effectively reduced the level of tumor EVs in the extracellular environment, thereby increasing sensitivity to chemotherapy and reducing tumor progression[6-13]. This evidence concerns the gene RAB27A and neoplasm.