Similarly, increased levels of inflammatory-associated miRNAs have been detected in SF EVs from RA, such as miR-143-3p, miR-150-5p, miR-185-5p, miR-21-5p, miR-223-3p, miR-378a-3p, and miR-503-5p, through the targeting of IGF1R (insulin-like growth factor 1 receptor), VEGFA (vascular endothelial growth factor A), and BCL1 (an apoptosis regulator)[76]. The gene discussed is IGF1R; the disease is rheumatoid arthritis.