CLOCK and metabolic syndrome: Similarly, there is an accumulating body of evidence from human experimental (Spiegel et al., 1999; Buxton et al., 2012), epidemiological (Kim et al., 2013; Bernsmeier et al., 2015; Morris et al., 2016; Wijarnpreecha et al., 2016; Marjot et al., 2021; Potter et al., 2016), and genetic (Sookoian et al., 2007) studies implicating an important role for the circadian clock and sleep cycle in the pathogenesis of the metabolic syndrome, specifically MASLD.