MARVELD2 and nodular sclerosis classical Hodgkin lymphoma: In this study, we used NGS and Sanger sequencing to evaluate a family with NSHL, identifying a rare mutation (c.663G>A) in MARVELD2. The mutation caused the tricellulin protein to become truncated at glutamic acid position 221, resulting in a 60.4% amino acid loss compared to the wild-type protein.