EVs could also have a role in Alzheimer’s disease pathogenesis, since EVs in the CSF contain high levels of Aβ, which is toxic to neurons cultured in vitro[18] and in animal models in vivo[19], and Tau protein, which can be transmitted to neurons, inducing Tau aggregation[20,21]. Here, MAPT is linked to early-onset autosomal dominant Alzheimer disease.