miR-186-5p in MSC-EVs binds to the 3'-UTR of Smad5 and thus down-regulates Smad5 expression, attenuating renal injury/fibrosis in a unilateral ureteral obstruction model by inhibiting ECM protein aggregation and epithelial-mesenchymal transition[70]. This evidence concerns the gene SMAD5 and Ureteral obstruction.