In addition, Western blotting analysis of GBM hypoxia exosome proteins revealed increased levels of lysine-6-oxidase (LOX), disintegrin, thrombospondin-1 (TSP1), A disintegrin-like and metalloproteinase with thrombospondin type 1 motif 1, (ADAMTS1), and VEGF. The gene discussed is THBS1; the disease is glioblastoma.