These factors were as follows: (1) being male, (2) having a late diagnosis, (3) having an advanced performance status, (4) the presence of splenomegaly, (5) a high-ELTS stratification score, (6) a kinase domain BCR::ABL1 mutation, and (7) reaching a CHR after more than 30 days. This evidence concerns the gene ABL1 and Splenomegaly.