Lavin et al. described the first innate immune cell atlas of early lung adenocarcinoma lesions, reporting the impaired balance between infiltrating effector CD8+ T cells and T regulatory cells (Tregs) at the tumour site, observed as a decline in T cells expressing granzyme B and IFN-γ coupled with an expansion of suppressor T cells[21]. This evidence concerns the gene CD8A and neoplasm.