CTNNB1 and acute myeloid leukemia: In general,β-catenin (beta-catenin) has been shown to play a role in the formation of leukemicstem cells (LSCs) in AML.40,41 However, directly targeting β-catenin for therapy is challengingdue to the lack of effective pharmacological interventions.40,41 This study further found that GPR84is highly expressed in LSCs compared to normal HSCs.