Next, P2RY8 is a purinergic receptor that has been characterized to promote B-celldevelopment and migration while being highly expressed in lymphocytes.80 In support of our findings, a study found P2RY8 to be downregulated during leucocytedifferentiation and undifferentiated promyelocytic leukemia cell line to also have adownregulation of P2RY8.81 This evidence concerns the gene P2RY8 and leukemia.