Advanced tools such as RNA-seq provided valuable insight into the dysregulations of orphanGPCRs including 13 upregulated (including GPR85, GPR183, and GPR82) and 18 significantlydownregulated (such as GPR45, GPR182, and P2RY8) within childhood ALL patients. The gene discussed is ACKR5; the disease is acute lymphoblastic leukemia.