GPR183 and acute myeloid leukemia: Next, it has beendemonstrated that elevated GPR183 expression correlates with poor prognosis in AML,regardless of age and treatment response.54 Knockdown (KD) of GPR183using specific short hairpin RNA in AML cells inhibited proliferation, promoted apoptosis,and reduced tumor burden in vivo, suggesting therapeutic potential.54Furthermore, GPR183 overexpression exacerbated AML growth and drug resistance.