However, knockout studies showed GPR45 to have acorrelation with glucose intolerance, causing a higher level of glucose in thebloodstream.72 This is important as further studies have shown thathigh levels of glucose lead to leukemia cell growth and progression, particularly in AMLwhere it is also correlated with a 40% higher death rate.73 Notably,research into the roles of GPR45 in AML and ALL should be of interest in the future. This evidence concerns the gene GPR45 and acute lymphoblastic leukemia.