Another potential binding ligand named CXCL12 is a homeostatic chemokine, and itactivates or stimulates the migration of hematopoietic progenitor and differentleukocytes.75 According to a study, a higher expression of CXCL12 hasbeen correlated to pediatric ALL patients.76,77 Therefore, downregulation of GPR182 could potentiallyimpact the progression of this disease. This evidence concerns the gene ACKR5 and acute lymphoblastic leukemia.