However, the suppression of GPR84expression led to reduced cell growth by inducing G1-phase cell-cycle arrest inpreleukemic stem cells (pre-LSCs), which in turn decreased the frequency of LSCs andimpaired the reconstitution of AML in mouse and human models.40Overall, this highlights GPR84 as a potential contributor to AML progression. The gene discussed is GPR84; the disease is acute myeloid leukemia.