Initially recognizedfor its role in immune responses and inflammation, emerging evidence suggests potentialimplications of GPR183 dysregulation in leukemic pathogenesis.54 Thisis further supported by the fact that GPR183 agonist, 7α,25-dihydroxycholesterol(7α,25-OHC), has been linked to direct cell migration of B cells and T cells, bothknown to impact ALL progression.55 Here, GPR183 is linked to acute lymphoblastic leukemia.