Interestingly, astudy revealed GPR85 as a novel functional receptor for CXCL14activity.62,63CXCL14, described as a homeostatic chemokine, recruits macrophages playing a crucial rolein enhancing macrophage infiltration as well as proliferation and migration.64 Macrophages are also known to participate in leukemia progression, bysecreting cytokines and growth factors.65,66 Potentially, GPR85 may not directly be involved in ALLprogression but can serve as a communicator to other receptors driving the development ofALL. This evidence concerns the gene GPR85 and leukemia.