F8 and hemophilia: Because FVIII or FIX replacement therapy is not effectivein patientswith hemophilia with inhibitors, alternative treatment options playa central role in preventing and managing bleeding disorders in theseindividuals.4,5 This review provides a brief overviewof the current understanding of the pathophysiology and treatmentof hemophilia with inhibitors, discusses new therapeutic agents, andevaluates their pharmacological properties, benefits, and associatedchallenges.