MIB1 and glioma: CircMIB1 is an emerging molecule that has not been studied and reported in gliomas and other diseases, but its parental protein, MIB1, is an E3 ubiquitin ligase required for the activation of the Notch pathway, and dysregulation of Notch signalling has been associated with cell transformation and tumourigenesis in various types of cancer (Li et al., 2018).