Another study also showed that circPTN promotes glioma growth and stemness by sponging miR-145-5p and miR-330-5p, this results in increased expression of NES, CD133, SOX9 and SOX2, which promotes self-renewal of glioma stem cells and regulates gliomagenesis (Chen et al., 2019). The gene discussed is SOX9; the disease is central nervous system cancer.