Interestingly, in the logistic regression model established in this study, after adjusting for common risk factors such as BP, FBG, lipids, HOMA-IR, UA, hs-CRP, age, and eGFR, RBP4 continued to exhibit significant ORs for the presence of CKD (OR: 1.862, 95%CI: 1.057-3.279) when comparing the top quartile with the bottom quartile. The gene discussed is RBP4; the disease is chronic kidney disease.