HFpEF: heart failure with preserved ejection fraction; HFmrEF: heart failure with mid-range ejection fraction; LVEF: left ventricular ejection fraction; CV: cardiovascular; HHF: heart failure hospitalizations; HR: hazard ratio; CI: confidence interval; eGFR: estimated glomerular filtration rate; KCCQ-OSS: Kansas City Cardiomyopathy Questionnaire-Overall Summary Score; QoL: quality of life; SGLT2: sodium-glucose cotransporter-2. Here, SLC5A2 is linked to heart failure.