PTGS2 and cancer: More importantly, we demonstrated that Ir-ART has a strong STAT3 inhibitory activity, which can inhibit the phosphorylation of STAT3 and the expression of related proteins cyclin B1, MMP9, and COX-2, which not only enabled Ir-ART to successfully inhibit the migration of cancer cells, but also amplified the antitumor immune response by remodeling the tumor immunosuppressive microenvironment.