More recently, Giannandrea et al. investigated EV-associated Notch2 in the tumor microenvironment, revealing that multiple myeloma cells can transfer Notch2 to distant cells via EVs, increasing Notch signaling in recipient cells and stimulating the pro-tumorigenic behavior of endothelial cells and osteoclasts[103]. The gene discussed is NOTCH2; the disease is plasma cell myeloma.