Furthermore, it was observed a decrease in p53 tumor suppressor activity and an increase in proliferation, migration, and production of matrix metalloproteinase 2 (MMP2) of pre-adipocytes exposed to EVs secreted from liposarcoma, carrying mouse double minute 2 (MDM2) DNA, thereby contributing to the establishment of a pre-metastatic niche that facilitates tumor growth and colonization[153]. Here, MMP2 is linked to liposarcoma.