NK cells exert important anti-tumor immune activity by recognizing and killing tumor cells that express abnormal proteins or lack MHC-I molecules, and also secrete pro-inflammatory cytokines such as IFN-γ and TNF-α to activate and enhance the anti-tumor immune response of other immune cells (e.g., DCs and T cells) response (Fang et al., 2022). The gene discussed is IFNG; the disease is neoplasm.