FGFR2 and cholangiocarcinoma: In recent years, targeted therapies, including those for fibroblast growth factor receptor 2 (FGFR2) fusions, isocitrate dehydrogenase 1 (IDH1) mutations, B-Raf proto-oncogene serine/threonine kinase (BRAF) V600E mutations, neurotrophic tyrosine receptor kinase (NTRK) fusions, and human epidermal growth factor receptor 2 (HER2) amplifications (Lamarca et al., 2022), along with immune checkpoint inhibitors (ICIs), are rapidly changing the treatment landscape for patients with advanced CCA (Mauro and Forner, 2023).