The orphan nuclear receptor small heterodimer partner (SHP) alleviates chronic hepatitis C virus (HCV)-induced hepatic fibrosis; SHP regulates gluconeogenesis through Forkhead box O1 acetylation via histone deacetylase 9 (HDAC9) and controls lipogenesis by upregulating the sterol regulatory element binding protein 1c via SUMOylation of the liver X receptor α (Chen et al., 2019). The gene discussed is NR0B2; the disease is Hepatic fibrosis.