NR5A2 and renal fibrosis: In renal fibrosis, the nuclear receptor subfamily 5 group A member 2 (NR5A2) and Ubc9 are highly expressed in the kidney, while the K224R mutation of SUMOylated NR5A2 fails to upregulate calreticulin to drive fibrosis (Arvaniti et al., 2016; Politis and Charonis, 2022).