Most of these genes were hub genes in the regulatory network and were found to be involved in HIF-1 signaling pathway, autophagy pathway in animals, MAPK signaling pathway, mTOR signaling pathway, Jak-STAT signaling pathway, TGF-beta signaling pathway, PI3K-Akt signaling pathway, Wnt signaling pathway, transcriptional misregulation in cancer, and microRNAs in cancer. Here, AKT1 is linked to cancer.