Pathologically, AD exhibits the senile plaque containing β amyloid protein (Aβ), the neurofibrillary tangle with hyperphosphorylated tau protein, and degeneration and loss of acetylcholinergic neurons (Rajmohan and Reddy, 2017; Marcucci and Kleiman, 2021; Li and Gu, 2023). Here, MAPT is linked to Alzheimer disease.