EVs naturally contain lysosomal components including heparan-alpha-glucosaminide N-acetyltransferase (HGSNAT)[50], beta-glucocerebrosidase (GBA), N-acetylgalactosamine-6-sulfate sulfatase (GALNS)[127], cystinosis (CTNS)[128], deficient in MPS III, Gaucher, MPS IVA, and Cystinosin respectively. This evidence concerns the gene HGSNAT and mucopolysaccharidosis type 4A.