UM is also ideal in this regard as a panel of four mutually-exclusive mutated genes with known mutational hotspots, namely GNAQ, GNA11, PLCB4 and CYSLTR2, which encodes for guanine nucleotide-binding protein G(q) subunit α, guanine nucleotide-binding protein subunit α11, phospholipase C β4, and cysteinyl leukotriene receptor 2 respectively, collectively accounts for almost all UM cases thereby allowing tumor agnostic approaches (15–17). The gene discussed is GNA11; the disease is neoplasm.