While it is unclear how CVB4 regulates hsa-miR-AMC1 expression, a study of CVB3-induced viral myocarditis showed that miR-222 expression was promoted by a complex that includes Dicer and the adenosine deaminases acting on RNA (ADAR) enzyme, ADAR1p150 (47). The gene discussed is ADAR; the disease is viral myocarditis.