NRF1 and type 1 diabetes mellitus: Furthermore, enriched transcription factor and protein-protein interactions analysis of hsa-miR-AMC1 identified association with nuclear factor, erythroid 2 (NFE2), a known regulator of the heme oxygenase 1 (HMOX1) gene (59) for which down-regulation is associated with delayed onset of T1D (26), as well as with nuclear respiratory factor 1 (Nrf1), for which decreased function is associated with loss of β cell activities (60).