In conclusion, our mapping study of the transmembrane potential (Vm) and intracellular Ca2+ transient (CaT) in intact hearts of RyR2-R2474S mice, in particular the analysis of voltage-calcium latency, provide new insights into the arrhythmogenic mechanisms of CPVT at tissue level. This evidence concerns the gene RYR2 and catecholaminergic polymorphic ventricular tachycardia.