RYR2 and catecholaminergic polymorphic ventricular tachycardia: Previous research has identified several genes associated with CPVT and sarcoplasmic reticular (SR) Ca2+ release, including RYR2, FKBP12.6, CASQ2, TRDN, and CALM1-3[[6], [7], [8], [9], [10], [11], [12]].