Table 5 below presents key research milestones in the study of ferroptosis, providing an essential reference for significant developments in this field, especially highlighting the role of different proteins like SMURF2, Ferroptosis Suppressor Protein 1 (FSP1), and Dihydroorotate Dehydrogenase (DHODH) in regulating this form of cell death Each entry includes a brief focus on the study and the key findings, which collectively emphasize the potential of targeting ferroptosis as a novel approach in cancer therapy. Here, AIFM2 is linked to cancer.