As expected, we observed a significant decrease in cell proliferation (Figure 6A) and anchorage-independent growth (Figure 7), and a significant increase in apoptosis (Figure 6B) in OSCC cells co-transfected with pTOPORS-3′UTR-S and pmiR-198 as compared to those co-transfected with pTOPORS or pTOPORS-3′UTR-M and pmiR-198, confirming that miR-198 regulates various hallmarks of cancers, in part, by directly targeting the 3′UTR of TOPORS. Here, TOPORS is linked to cancer.