SMARCA1 and cancer: When a subunit in the SWI/SNF complex is mutated, the interactions between the subunits within the complex are altered, leading to disruption of the normal assembly pathways of the subunits of the complex and stabilization of the subunit proteins, which may also lead to altered accessibility of chromatin enhancers and promoters, resulting in the transcriptional activity of genes being compromised, and thus causing cancer.