BRG1 inhibition has been observed to prevent panIN formation and block panIN-derived PDAs by inducing apoptosis.SMARCA4 binds to the SOX9 promoter and helps to initiate the transcription of SOX9.SOX9 has been shown to affect tumor proliferation, and SOX9 knockdown has a pro-apoptotic effect (117). This evidence concerns the gene SMARCA4 and neoplasm.