HLA-DPB1 specific T cell receptor transduced CD4 and CD8 T cells showed strong reactivity to AML in vitro. CD4 cells were able to eliminate leukemia blasts in AML engrafted mice. However, strong cross-reactivity with non-hematopoietic cells is a concern and safety mechanisms will have to be investigated. The gene discussed is HLA-DPB1; the disease is acute myeloid leukemia.