CD8A and acute myeloid leukemia: LAG3 expression on CD8+ T cells co-cultured with irradiated K1: 11.8% ± 2.4 v. PBMC co-cultured with non-irradiated K1 cells: 17.5% ± 2.5; n=4, P=0.002. Anti-LAG3 antibody in PBMC co-cultured with non-irradiated AML cells: 16.3% IFNg on CD8+ T cells, 6.5% CD137 on CD8+ T cells, 1.7% Tregs. Without anti-LAG3 antibody: 6.6 % IFNg on CD8+ T cells, 4.1% CD137 on CD8+ T cells, Tregs 3.8% (IFNg: P=0.01, n=4; CD137: p=.007, n=4; Tregs: P=.04, n=4)