GNRH1 and polycystic ovary syndrome: Clinically, there are several methods used to reduce LH levels in women with PCOS.Pituitary downregulation using GnRH agonists significantly lowers the LH level in women withPCOS (Homburg et al., 1993;Balen et al., 1993a).However, the GnRH agonist long protocol increases the risk of ovarian hyperstimulationsyndrome (OHSS) in women with PCOS compared with the GnRH antagonist protocol.