Examples include human epidermal growth factor receptor-2 (HER2) expressed in certain sarcomas, IL-13Rα2 expression in glioblastoma multiforme (GBM), GD2 expression in neuroblastoma, epidermal growth factor receptor (EGFR) expression in non-small-cell lung carcinoma (NSCLC), breast, gastroesophageal colorectal cancers, and recurrent GBM, as well as Carcinoembryonic antigen (CEA) expression in colorectal cancer (CRC), lung, breast, and pancreatic cancers and claudin18.2, expression is noted in 70% of primary gastric cancers (35–44). The gene discussed is CEACAM5; the disease is non-small cell lung carcinoma.