Alzheimer's disease research remained a focal point, with studies revealing how EE reduces amyloid plaque buildup, enhances synaptic plasticity, and promotes neurogenesis through neurotrophins like BDNF, thereby supporting overall hippocampal health (Turner and Lewis, 2003; Jankowsky et al., 2003). The gene discussed is BDNF; the disease is early-onset autosomal dominant Alzheimer disease.