Research in this area focuses on how enriched environments can mitigate or reverse cognitive deficits, synaptic damage, and behavioral abnormalities, with the use of genetic models like APP/PS1 mice for Alzheimer's (Fulopova et al., 2021) and Ts65Dn mice for Down syndrome (Toma et al., 2020) underscoring the relevance of EE as a non-pharmacological intervention. This evidence concerns the gene APP and Down syndrome.