Biomarkers of synaptic pathology (e.g., neurogranin, Growth associated protein 43 (GAP‐43), Synaptosomal‐associated protein 25 (SNAP‐25), Neuronal pentraxin‐2 (NPTX2)) are correlated with disease progression or cognitive decline in AD.27, 28, 29. This evidence concerns the gene GAP43 and Alzheimer disease.