Univariate Cox regression analysis demonstrated a significant association between DFS in HCC patients and several factors: larger tumor size (P =0 .001), advanced BCLC stage (P <0 .001) or Child stage (P =0 .042), reduced FAM96B expression (P =0 .001), and presence of distant metastasis (P = 0.002) (Table 3). The gene discussed is CIAO2B; the disease is hepatocellular carcinoma.