LncRNAs have been proven to have great potential in regulating cell activity, participating in tumor treatment, and affecting the prognosis of patients.13,14 There is also evidence that lncRNAs bring new possibilities in the treatment and prognosis of digestive tumors.15 For instance, Huang et al proposed that lncRNA PDIA3P1 promotes the progression of esophageal squamous cell carcinoma by modulating OCT4 in a recent report.16 Here, POU5F1 is linked to esophageal squamous cell carcinoma.