APOE and Alzheimer disease: For example, disease‐associated microglia (DAM) and other microglial translational signatures associated with neurodegeneration and AD (in mice and humans) also show an increase in some of these lipid‐associated transcripts, including APOE and LPL, as do white matter associated microglia, which are found in the white matter of aged mice (Keren‐Shaul et al., 2017; Krasemann et al., 2017; Safaiyan et al., 2021; Sala Frigerio et al., 2019; Srinivasan et al., 2020; Vecchiarelli & Tremblay, 2023b).