Consider the severity of liver disease to determine whether treatment should be initiated for patients with ALT of 1-2x ULNTreatment is recommended if elevated HBV DNA (≥20,000 IU/mL for HBeAg-positive or ≥2,000 IU/mL for HBeAg-negative CHB) and either ALT ≥2x ULN or evidence of significant histological disease. Here, GPT is linked to liver disorder.