Human IL-30 can be found as a membrane-anchored cytokine, expressed by cancer cells and by tumor-infiltrating macrophages and myeloid-derived suppressor cells (MDSCs) [33, 35] and plays a critical role in tumor onset and progression, by triggering a cascade of proinflammatory and oncogenic events, in association with the development of a robust vascular network [36, 37]. Here, IL27 is linked to cancer.