The most enriched transcription factor in males with myocarditis was signal transducer and activator of transcription (STAT)1, which is known to mount interferon (IFN) and T helper (Th)1/M1 immune responses that clear CVB3 infection during myocarditis [18, 19] (Fig. 7a). The gene discussed is IFNA1; the disease is myocarditis.