In contrast, the DLBTau+ patient exhibited extensive pTau staining, which co-localized with α-synuclein aggregates near DAPI-positive nuclei, suggesting aggregation within cellular bodies (Fig. 3e).These analyses confirm the co-occurrence of tau and α-synuclein aggregates in the DLBTau+ group and validated our DLB subgrouping based on proteomic quantification. This evidence concerns the gene SNCA and Lewy body dementia.