In an unsupervised approach to identify costimulatory molecules which could potentiate Vδ2- γδ T-cell response, LILRB1 blockade was found to dramatically reduce Vδ2- γδ cytolysis of large B-cell lymphoma cells, with no effect on Vδ2 + γδ T-cells [38]. This evidence concerns the gene LILRB1 and B-cell non-Hodgkin lymphoma.